Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment

Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment

BACKGROUND Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) mass. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthma. Recent evidence indicates that a deficiency of 1...

Upregulation of a disintegrin and metalloproteinase-33 by VEGF in human airway smooth muscle cells: Implications for asthma

Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling. Features of airway remodeling include increased airway smooth muscle (ASM) mass. A disintegrin and metalloproteinase (ADAM)-33 has been identified as playing a role in the pathophysiology of asthma. ADAM-33 is expressed in ASM cells and is suggested t...

–Induced Cyclooxygenase-2 Expression in Human Airway Smooth-Muscle Cells

We studied the effect of endogenous and exogenous prostaglandin E 2 (PGE 2 ), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 b –induced COX-2 expression, using primary cultures of human bronchial smooth-muscle cells (HBSMC). Treatment with exogenous PGE 2 resulted in enhanced expression of IL-1 b –induced COX-2 protein and messenger RNA (mRNA) a...

effects of mitochondrial atp-sensitive potassium channels on the proliferation and secretion of human airway smooth muscle cells.

bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

Muscle Cells Proliferation of Human Airway Smooth Cells and Asthma: Its Effect on the Regulation of Activin A Expression in Mast